This is the answer that I sent him, which may be of interest to other people. "Can NONMEM calculate etas for the subject, when the thetas, omegas and epsilons are fixed to the previously obtained values?" I told him that, with the POSTHOC option of the $ESTIMATION record, NONMEM can obtain individual etas via Bayesian method. Does anyone know any application programs for Bayesian estimation. "I attempt to estimate individual eta's from individual measurements using pre-determined theta's, omega's and epsilon's which are obtained by NONMEM methods from a set of data. Recently, Masaki Hiraoka asked this question: So, the errors in Bayesian estimation should be evaluate using relative or absolute error models which give preferable likelyhood.Īny programs or macros executable directly on PC, using spreadsheet for Windows, or with WinNonlin is preferable. However, when one estimates using observed values in a wide rage, relative error is suitable for large values and absolute error is for small values near to lower quantitation limit.
I think it is difficult to understand what two-error-model means, because an estimate for an individual error is only one value that is the difference between observed and estimated concentrations. Does anyone know any application programs for Bayesian estimation that covers the following requirement:įeasiblility which allows to use any models described using subroutins of ADVAN and TRANS in the NONMEM.īoth relative and absolute errors(epsilon's) can be modeled simultaneously.
I attempt to estimate individual eta's from individual measurements using pre-determined theta's, omega's and epsilon's which are obtained by NONMEM methods from a set of data. Subject: Any tools for Bayesian estimation?
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